Material extrusion 3D printing (ME3DP) based on fused deposition modeling (FDM) technology is currently the most commonly used additive manufacturing method. However, ME3DP suffers from a limitation of compatible materials and typically relies upon amorphous thermoplastics, such as acrylonitrile butadiene styrene (ABS). The work presented here demonstrates the development and implementation of binary and ternary polymeric blends for ME3DP. Multiple blends of acrylonitrile butadiene styrene (ABS), styrene ethylene butadiene styrene (SEBS), and ultrahigh molecular weight polyethylene (UHMWPE) were created through a twin screw compounding process to produce novel polymer blends compatible with ME3DP platforms. Mechanical testing and fractography were used to characterize the different physical properties of these new blends. Though the new blends possessed different physical properties, compatibility with ME3DP platforms was maintained. Also, a decrease in surface roughness of a standard test piece was observed for some blends as compared with ABS.